Microbiota-derived molecules play critical roles in health and disease, and across ecosystems; yet their structural and functional characterization remains limited. Indeed, microbiomes have 100–150 times the metabolic capacity of their hosts, but currently, only about 10% of metabolomic data can be matched to known molecular structures, and just 1–2% can be traced to microbial origins. To truly understand and harness microbiomes, we need new tools to uncover the full diversity of microbial metabolites and define their functions. 

This conference will highlight cutting-edge technologies for discovering microbiome-derived metabolites, mapping the genes behind their production, and revealing their functional roles. Specifically, we will focus on metabolites that arise from microbial metabolism of (1) host-derived compounds, (2) dietary molecules, and (3) xenobiotics—including plasticizers, pollutants, drugs, and environmental molecules absorbed through skin or inhalation. In addition, the program will examine microbial biosynthesis from genetic elements such as gene clusters found in bacteria, archaea, fungi, and even phages. These insights hold promise for transformative applications in managing health and disease across medicine, agriculture, and environmental sciences. 

Check out the speaker highlights in the video below: